Volume 12, Issue 1 (2024)                   Health Educ Health Promot 2024, 12(1): 47-52 | Back to browse issues page


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Rusdi B, Abdullah A, Wahiduddin W, Maria I, Salmah U, Nazaruddin B. Analysis of Maternal Risk Factors Associated with Non-Syndromic Orofacial Cleft Among Newborns at Celebes Cleft Center in Makassar. Health Educ Health Promot 2024; 12 (1) :47-52
URL: http://hehp.modares.ac.ir/article-5-72833-en.html
1- Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
2- Department of Biostatistics, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
3- Department of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
Abstract:   (500 Views)
Aims: Non-syndromic orofacial cleft (NSOFC) is a congenital facial anomaly of cleft lip, cleft palate, or both, most commonly affecting the craniofacial region and oral cavity. The etiology is multifactorial, combining endogenous (genetic) with environmentally influenced exogenous factors. This study aimed to determine and analyze the risk factors for the incidence of NSOFC.
Materials & Methods: This case-control study was conducted at Celebes Cleft Center in Makassar. The case group consisted of 80 newborns with cleft lip and palate, and the control group consisted of 106 newborns without cleft lip and palate. Data collected included sex, type of NSOFC, age of respondents, educational level, risk factors for NSOFC incidence from patient medical records and interview results. Data were collected in an Excel table and analyzed using the Stata program using the Chi-square test and multiple logistic regression.
Findings: The results showed that NSOFC mostly occurred in newborns of male gender (58.75%). The most common type of NSOFC was cleft lip accompanied by cleft palate then cleft lip, and the least was cleft palate. Maternal risk factors that were significant for the incidence of cleft lip and palate/NSOFC were maternal occupation (OR=25.037; 95%CI=5.812-222.113; p<0.001), family history of orofacial cleft (OR=11.666; 95%CI=1.493-522.396; p=0.005), history of tobacco smoke exposure during pregnancy (OR=2.64; 95%CI=1.355-5.187; p=0.002). The most dominant risk factor was maternal occupation.
Conclusion: The type of maternal occupation, family history of orofacial cleft, and maternal history of tobacco smoking are risk factors for the incidence of lip and palate cleft or NSOFC.
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Article Type: Original Research | Subject: Health Care
Received: 2023/11/2 | Accepted: 2024/01/11 | Published: 2024/01/20
* Corresponding Author Address: Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Perintis Kemerdekaan KM 10, Makassar, Indonesia. Postal Code: 91121 (budimanrusdi21@gmail.com)

References
1. Triwardhani A, Permatasari G, Sjamsudin J. Variation of non-syndromic cleft lip/palate in Yayasan Surabaya cleft lip/palate center Surabaya, Indonesia. J Int Oral Health. 2019;11(4):187-90. [Link] [DOI:10.4103/jioh.jioh_6_19]
2. Mirilas P, Mentessidou A, Kontis E, Asimakidou M, Moxham BJ, Petropoulos AS, et al. Parental exposures and risk of nonsyndromic orofacial clefts in offspring: A case-control study in Greece. Int J Pediatr Otorhinolaryngol. 2011;75(5):695-9. [Link] [DOI:10.1016/j.ijporl.2011.02.018]
3. Lin Y, Shu S, Tang S. A case-control study of environmental exposures for nonsyndromic cleft of the lip and/or palate in eastern Guangdong, China. Int J Pediatr Otorhinolaryngol. 2014;78(3):545-51. [Link] [DOI:10.1016/j.ijporl.2014.01.002]
4. Nahas LD, Alzamel O, Dali MY, Alsawah R, Hamsho A, Sulman R, et al. Distribution and risk factors of cleft lip and palate on patients from a sample of Damascus hospitals-A case-control study. Heliyon. 2021;7(9):E07957. [Link] [DOI:10.1016/j.heliyon.2021.e07957]
5. Wang W, Guan P, Xu W, Zhou B. Risk factors for oral clefts: A population-based case-control study in Shenyang, China. Paediatr Perinat Epidemiol. 2009;23(4):310-20. [Link] [DOI:10.1111/j.1365-3016.2009.01025.x]
6. Cheshmi B, Jafari Z, Naseri MA, Davari HA. Assessment of the correlation between various risk factors and orofacial cleft disorder spectrum: A retrospective case-control study. Maxillofac Plast Reconstr Surg. 2020;42(1):26. [Link] [DOI:10.1186/s40902-020-00270-7]
7. Acuña-González G, Medina-Solís CE, Maupomé G, Escoffie-Ramírez M, Hernández-Romano J, Márquez-Corona M, et al. Family history and socioeconomic risk factors for non-syndromic cleft lip and palate: A matched case-control study in a less developed country. Biomedica. 2011;31(3):381-91. [Link] [DOI:10.7705/biomedica.v31i3.378]
8. Nguyen RHN, Wilcox AJ, Moen BE, McConnaughey DR, Lie RT. Parent's occupation and isolated orofacial clefts in Norway: A population-based case-control study. Ann Epidemiol. 2007;17(10):763-71. [Link] [DOI:10.1016/j.annepidem.2007.04.008]
9. Xu LF, Zhou XL, Wang Q, Zhou JL, Liu YP, Ju Q, et al. A case-control study of environmental risk factors for nonsyndromic cleft of the lip and/or palate in Xuzhou, China. Biomed Environ Sci. 2015;28(7):535-8. [Link]
10. Leite ICG, Koifman S. Oral clefts, consanguinity, parental tobacco and alcohol use: A case-control study in Rio de Janeiro, Brazil. Braz Oral Res. 2009;23(1):31-7. [Link] [DOI:10.1590/S1806-83242009000100006]
11. Hagberg C, Larson O, Milerad J. Incidence of cleft lip and palate and risks of additional malformations. Cleft Palate Craniofac J. 1998;35(1):40-5. [Link] [DOI:10.1597/1545-1569_1998_035_0040_ioclap_2.3.co_2]
12. Agbenorku P. Orofacial clefts: A worldwide review of the problem. ISRN Plast Surg. 2013;2013:348465. [Link] [DOI:10.5402/2013/348465]
13. Angulo-Castro E, Acosta-Alfaro LF, Guadron-Llanos AM, Canizalez-Roman A, Gonzalez-Ibarra F, Osuna-Ramirez I, et al. Maternal risk factors associated with the development of cleft lip and cleft palate in Mexico: A case-control study. Iran J Otorhinolaryngol. 2017;29(4):189-95. [Link]
14. Wang D, Zhang B, Zhang Q, Wu Y. Global, regional and national burden of orofacial clefts from 1990 to 2019: An analysis of the global burden of disease study 2019. Ann Med. 2023;55(1):2215540. [Link] [DOI:10.1080/07853890.2023.2215540]
15. Agency of Health Research and Development (Indonesia). Indonesian Basic Health Research in 2018 [RISKESDAS 2018]; 2018. [Link]
16. Agency of Health Research and Development (Indonesia). Indonesian Basic Health Research in 2013 [RISKESDAS 2013]; 2013. [Link]
17. Agency of Health Research and Development (Indonesia). South Sulawesi Province Report in Indonesian Basic Health Research in 2018 [RISKESDAS 2018]; 2018. [Link]
18. Wehby GL, Cassell CH. The impact of orofacial clefts on quality of life and healthcare use and costs. Oral Dis. 2010;16(1):3-10. [Link] [DOI:10.1111/j.1601-0825.2009.01588.x]
19. Golalipour MJ, Kaviany N, Qorbani M, Mobasheri E. Maternal risk factors for oral clefts: A case-control study. Iran J Otorhinolaryngol. 2012;24(4):187-92. [Link]
20. Jamilian A, Sarkarat F, Jafari M, Neshandar M, Amini E, Khosravi S, et al. Family history and risk factors for cleft lip and palate patients and their associated anomalies. Stomatologija. 2017;19(3):78-83. [Link]
21. Herkrath APCDQ, Herkrath FJ, Rebelo MAB, Vettore MV. Parental age as a risk factor for non-syndromic oral clefts: A meta-analysis. J Dent. 2012;40(1):3-14. [Link] [DOI:10.1016/j.jdent.2011.10.002]
22. Schnitzer PG, Olshan AF, Erickson JD. Paternal occupation and risk of birth defects in offspring. Epidemiology. 1995;6(6):577-83. [Link] [DOI:10.1097/00001648-199511000-00003]
23. Silva CM, Pereira MCM, Queiroz TB, Neves LTD. Family history in non-syndromic orofacial clefts: Is there a pattern?. Oral Dis. 2022;28(8):2194-203. [Link] [DOI:10.1111/odi.13942]
24. Tobing JN. Identification of exogenous risk factors for non-syndromic maternal orofacial clefts. Cermin Dunia Kedokteran. 2017;44(10):690-94. [Indonesian] [Link]
25. Egbunah UP. Environmental and genetic risk factors of nonsyndromic and syndromic cleft lip and palate-A literature review. Ann Surg Edu. 2022;3(1):1025. [Link]

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