Volume 10, Issue 1 (2022)
Health Educ Health Promot 2022, 10(1): 193-200 |
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Obeed F, Al-Saad L, Alrubayae I. The Prevalence of Hospital-Acquired Fungal Infections in Some Hospitals of Basrah Province. Health Educ Health Promot 2022; 10 (1) :193-200
URL: http://hehp.modares.ac.ir/article-5-59900-en.html
URL: http://hehp.modares.ac.ir/article-5-59900-en.html
1- Department of Biology, College of Science, University of Basrah, Basrah, Iraq
2- College of Pharmacy, University of Basrah, Basrah, Iraq
2- College of Pharmacy, University of Basrah, Basrah, Iraq
Abstract: (1063 Views)
Aim: This study was aimed at the prevalence of Hospital-Acquired Fungal Infections in Some Hospitals in Basrah Province.
Materials & Methods: Two hundred thirteen clinical specimens were collected from patients after 48h admission in Al–Faehaa Educational Hospital, AL-Sader Educational Hospital, and Pediatric Specialist Educational Hospital from November 2020 to April 2021.
Findings: The ages of patients ranged from 5 months to 80 years, 94 (44%) males and 119(56%) females. The highest prevalence of bacterial nosocomial infections was recorded in 5 months-10 years (27.5%), while the 21-30 years group showed a high prevalence of hospital-acquired fungal infections (22.02%). Furthermore, diabetic patients (43.7%) tended to be more susceptible to fungal infections. A fifty-nine yeast isolates were isolated from clinical specimens, all of which were identified morphologically, physiologically, and molecularly. The most fungal isolates were returned to the genus Candida that including Candida albicans (47.5%), C. glabrata (16.4%), C. tropicalis (11.48%), C. parapsilosis (9.84), C. krusei (4.91%), and C. dubliniensis (4.91%), C. lusitaniea (3.28%) in addition to 1.68% of Naganishia globose with significant difference (p≤0.05) among isolated species. Additionally, N. globose was firstly record as a nosocomial agent in Iraq.
Conclusion: Fungi have an important role as etiological agents of hospital-acquired infections, so, need more attention from health institutions for laboratory diagnosis of fungal infections in addition to antifungal susceptibility tests that assist physicians to select the suitable treatment for each case.
Materials & Methods: Two hundred thirteen clinical specimens were collected from patients after 48h admission in Al–Faehaa Educational Hospital, AL-Sader Educational Hospital, and Pediatric Specialist Educational Hospital from November 2020 to April 2021.
Findings: The ages of patients ranged from 5 months to 80 years, 94 (44%) males and 119(56%) females. The highest prevalence of bacterial nosocomial infections was recorded in 5 months-10 years (27.5%), while the 21-30 years group showed a high prevalence of hospital-acquired fungal infections (22.02%). Furthermore, diabetic patients (43.7%) tended to be more susceptible to fungal infections. A fifty-nine yeast isolates were isolated from clinical specimens, all of which were identified morphologically, physiologically, and molecularly. The most fungal isolates were returned to the genus Candida that including Candida albicans (47.5%), C. glabrata (16.4%), C. tropicalis (11.48%), C. parapsilosis (9.84), C. krusei (4.91%), and C. dubliniensis (4.91%), C. lusitaniea (3.28%) in addition to 1.68% of Naganishia globose with significant difference (p≤0.05) among isolated species. Additionally, N. globose was firstly record as a nosocomial agent in Iraq.
Conclusion: Fungi have an important role as etiological agents of hospital-acquired infections, so, need more attention from health institutions for laboratory diagnosis of fungal infections in addition to antifungal susceptibility tests that assist physicians to select the suitable treatment for each case.
Article Type: Original Research |
Subject:
Health Promotion Setting
Received: 2022/01/28 | Accepted: 2022/04/12 | Published: 2022/04/30
Received: 2022/01/28 | Accepted: 2022/04/12 | Published: 2022/04/30
References
1. Allegranzi B, Boyce J, Chraiti M, Larson E, Pittet D, Sax H. The World Health Organization hand hygiene observation method. Am J Infect Control. 2009;37(10):827-34. [Link] [DOI:10.1016/j.ajic.2009.07.003]
2. Magill SS, O'Leary E, Janelle SJ, Thompson DL, Dumyati G, Nadle, J et al. Emerging infections program hospital prevalence survey team: changes in prevalence of health care-associated infections in US hospitals. N Engl J Med. 2018;379(18):1732-44. [Link] [DOI:10.1056/NEJMoa1801550]
3. Suleyman G, Alangaden GJ. Nosocomial fungal infections: epidemiology, infection control, and prevention. Infect Dis Clin North Am. 2016;30(4):1023-52. [Link] [DOI:10.1016/j.idc.2016.07.008]
4. Perlroth J, Choi B, Spellberg B. Nosocomial fungal infections: epidemiology, diagnosis, and treatment. Med Mycol. 2007;45(4):321-46. [Link] [DOI:10.1080/13693780701218689]
5. Jose NV, Mudhigeti N, Asir J, Chandrakesan SD. Detection of virulence factors and phenotypic characterization of Candida isolates from clinical specimens. J Curr Res Sci Med. 2015;1(1):27-31. [Link]
6. Sanjukta B, Dutta AK. A comparative study on isolation and distribution of candida species with special reference to the risk factors associated with candidiasis. Int J Cell Biol Cell Process. 2021;7:66-70. [Link]
7. Blankenheim Y, Salmanton‐García J, Seifert H, Cornely OA, Koehler P. Attributable mortality of candidemia at a German tertiary hospital from 1997 to 2001 before the introduction of echinocandins. Mycoses. 2022;65(2):211-21. [Link] [DOI:10.1111/myc.13406]
8. Forbes BE, Sahm DF, Weissfeld AS. Bailey and scotts diagnostic microbiology. 12 Edition. Texas: Elsevier; 2007. [Link]
9. Sagar Aryal S. Germ tube test-principle, procedure, results, interpretation and limitations [Internet]. MicrobiologyInfo; 2015 [Cited 2020 Jul 01?]. Available from: https://microbiologyinfo.com/germ-tube-test-principle-procedure-results-interpretation-and-limitations/ [Link]
10. Mirhendi SH, Adin H, Shidfar MR, Kordbacheh P, Hashemi SJ, Moazeni M et al. Identification of pathogenic Candida species: PCR-fragment size polymorphism (PCR-FSP) method. Tehran Univ Med J. 2008;66(9):639-45. [Persian] [Link]
11. Al-Duboon AH. Candiduria and urinary candidiasis in Basrah, Iraq. J Basrah Res Sci. 2010;36(1). [Link]
12. Alrubayae IM, Al-Duboon AH, Majed M. Study of Candida spp. associated with urinary tract infections in Basra: urinary tract infection associated with Candida spp: Their identification, pathogenicity and susceptibility to antifungals. Germany: LAP LAMBERT Academic Publishing; 2013. p. 196. [Link]
13. Allaaeiby AIE, Al-Mousawi AA, Alrubayae I, Al-Saadoon A, Almayahi M. Innate pathogenic traits in oral yeasts. Karbala Int J Modern Sci. 2020;6(4):5. [Link] [DOI:10.33640/2405-609X.1984]
14. Alrubayae IM, Al-laaeiby A, Minati MH, ALibraheem SA. Determination of genetic relationships and pathogenicity of oral candidiasis etiological agents in pediatric malignant patients in Basrah province, Iraq. Sys Rev Pharm. 2020;11. [Link]
15. Abbas NF, Shani WS, Alrubyae IM. Evaluation of immunization efficacy for cell wall fraction antigen separated from clinical isolate of Candida albicans. Technium Bio Chem Med. 2021;2(2):60-76. [Link]
16. Matare T, Nziramasanga P, Gwanzura L, Robertson V. Experimental germ tube induction in Candida albicans: An evaluation of the effect of sodium bicarbonate on morphogenesis and comparison with pooled human serum. Biomed Res Int. 2017;2017:1976273. [Link] [DOI:10.1155/2017/1976273]
17. Mayer FL, Wilson D, Hube B. Candida albicans pathogenicity mechanisms. Virulence. 2013;4(2):119-28. [Link] [DOI:10.4161/viru.22913]
18. Sudbery P, Gow N, Berman J. The distinct morphogenic states of Candida albicans. Trends Microbiol. 2004;12(7):317-24. [Link] [DOI:10.1016/j.tim.2004.05.008]
19. Abeed FK, Alrubayae IM. Evaluation of virulence factors of clinical yeast isolates from nosocomial fungal infections with the determination of their antifungal susceptibility profile. Iran J Ichthyol. 2022;9:61-68. [Link]
20. Abu-Mejdad NM, Al-Badran AI, Al-Saadoon AH. A Novel report on killer yeast strains identification methods. Basrah J Agricult Sci. 2020;33(1):39-49. [Link] [DOI:10.37077/25200860.2020.32.1.04]
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