Volume 12, Issue 3 (2024)
Health Educ Health Promot 2024, 12(3): 449-458 |
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Risnawati R, Umrana S, Susanty S. Key Risk Factors of Dementia in Elderly Populations. Health Educ Health Promot 2024; 12 (3) :449-458
URL: http://hehp.modares.ac.ir/article-5-75495-en.html
URL: http://hehp.modares.ac.ir/article-5-75495-en.html
1- Department of Nursing, Karya Kesehatan School of Health Sciences, Kendari, Indonesia
2- Department of Nursing, Faculty of Medicine, University of Halu Oleo, Kendari, Indonesia
2- Department of Nursing, Faculty of Medicine, University of Halu Oleo, Kendari, Indonesia
Abstract: (543 Views)
Aims: Dementia and cognitive impairment can arise from a combination of genetic and modifiable factors. There is substantial evidence supporting the impact of modifiable factors, highlighting the urgent need for consistent evaluation. This study aimed to provide a narrative assessment of the risk factors associated with the incidence of dementia in older adults.
Information & Methods: This was a systematic review carried out in 2024. In this review, databases, including PubMed, ScienceDirect, Wiley Online Library, and ProQuest were searched for studies on risk factors associated with the incidence of dementia in the elderly. The review followed the PRISMA guidelines to systematically structure the report. The quality of the studies was evaluated using NIH criteria, and the risk of bias was assessed using the ROBINS-E tool. A total of 1,658 articles were collected in the initial search. After the screening process, 16 articles were deemed eligible.
Findings: Based on the collected studies, approximately 27 risk factors were categorized into four groups, including demographic factors, lifestyle, chronic diseases, and psychological disorders. The majority of the studies reviewed focused extensively on depression, while hypertension and a history of stroke also emerged as frequently discussed subjects.
Conclusion: Demographics, lifestyle, chronic diseases, and psychological disorders are risk factors for dementia among older adults.
Information & Methods: This was a systematic review carried out in 2024. In this review, databases, including PubMed, ScienceDirect, Wiley Online Library, and ProQuest were searched for studies on risk factors associated with the incidence of dementia in the elderly. The review followed the PRISMA guidelines to systematically structure the report. The quality of the studies was evaluated using NIH criteria, and the risk of bias was assessed using the ROBINS-E tool. A total of 1,658 articles were collected in the initial search. After the screening process, 16 articles were deemed eligible.
Findings: Based on the collected studies, approximately 27 risk factors were categorized into four groups, including demographic factors, lifestyle, chronic diseases, and psychological disorders. The majority of the studies reviewed focused extensively on depression, while hypertension and a history of stroke also emerged as frequently discussed subjects.
Conclusion: Demographics, lifestyle, chronic diseases, and psychological disorders are risk factors for dementia among older adults.
Keywords: Dementia [MeSH], Elderly [MeSH], Risk Factors [MeSH], Psychiatric Disorders [MeSH], Chronic Disease [MeSH]
Article Type: Systematic Review |
Subject:
Social Determinants of Health
Received: 2024/06/6 | Accepted: 2024/08/8 | Published: 2024/10/10
Received: 2024/06/6 | Accepted: 2024/08/8 | Published: 2024/10/10
References
1. Chertkow H, Feldman HH, Jacova C, Massoud F. Definitions of dementia and predementia states in Alzheimer's disease and vascular cognitive impairment: Consensus from the Canadian conference on diagnosis of dementia. Alzheimers Res Ther. 2013;5(Suppl 1):S2. [Link] [DOI:10.1186/alzrt198]
2. Stephan B, Birdi R, Tang EYH, Cosco TD, Donini LM, Licher S, et al. Secular trends in dementia prevalence and incidence worldwide: A systematic review. J Alzheimers Dis. 2018;66(2):653-80. [Link] [DOI:10.3233/JAD-180375]
3. Cao Q, Tan CC, Xu W, Hu H, Cao XP, Dong Q, et al. The prevalence of dementia: A systematic review and meta-analysis. J Alzheimers Dis. 2020;73(3):1157-66. [Link] [DOI:10.3233/JAD-191092]
4. Jia L, Quan M, Fu Y, Zhao T, Li Y, Wei C, et al. Dementia in China: Epidemiology, clinical management, and research advances. Lancet Neurol. 2020;19(1):81-92. [Link] [DOI:10.1016/S1474-4422(19)30290-X]
5. GBD 2019 Dementia Forecasting Collaborators. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: An analysis for the Global Burden of Disease Study 2019. Lancet Public Health. 2022;7(2):e105-25. [Link]
6. Cheng ST. Dementia caregiver burden: A research update and critical analysis. Curr Psychiatry Rep. 2017;19(9):64. [Link] [DOI:10.1007/s11920-017-0818-2]
7. Shon C, Yoon H. Health-economic burden of dementia in South Korea. BMC Geriatr. 2021;21(1):549. [Link] [DOI:10.1186/s12877-021-02526-x]
8. Burks HB, Des Bordes JKA, Chadha R, Holmes HM, Rianon NJ. Quality of life assessment in older adults with dementia: A systematic review. Dement Geriatr Cogn Disord. 2021;50(2):103-10. [Link] [DOI:10.1159/000515317]
9. Hermann P, Zerr I. Rapidly progressive dementias-aetiologies, diagnosis and management. Nat Rev Neurol. 2022;18:363-76. [Link] [DOI:10.1038/s41582-022-00659-0]
10. Jenkins LM, Wang L, Rosen H, Weintraub S. A transdiagnostic review of neuroimaging studies of apathy and disinhibition in dementia. Brain. 2022;145(6):1886-905. [Link] [DOI:10.1093/brain/awac133]
11. Warren J, Collinge J, Fox N, Mead S, Mummery C, Rohrer J, et al. Cognitive impairment and dementia. In: Neurology: A queen square textbook. Hoboken: John Wiley & Sons; 2024. p. 319-67. [Link] [DOI:10.1002/9781119715672.ch11]
12. Lindeza P, Rodrigues M, Costa J, Guerreiro M, Rosa MM. Impact of dementia on informal care: A systematic review of family caregivers' perceptions. BMJ Support Palliat Care. 2020;14:e38-49. [Link] [DOI:10.1136/bmjspcare-2020-002242]
13. Murphy C, De Laine C, Macaulay M, Hislop Lennie K, Fader M. Problems faced by people living at home with dementia and incontinence: causes, consequences and potential solutions. Age Ageing. 2021;50(3):944-54. [Link] [DOI:10.1093/ageing/afaa262]
14. Angeles RC, Berge LI, Gedde MH, Kjerstad E, Vislapuu M, Puaschitz NG, et al. Which factors increase informal care hours and societal costs among caregivers of people with dementia? A systematic review of Resource Utilization in Dementia (RUD). Health Econ Rev. 2021;11(1):37. [Link] [DOI:10.1186/s13561-021-00333-z]
15. Farina N, Hicks B, Baxter K, Birks Y, Brayne C, Dangoor M, et al. DETERMinants of quality of life, care and costs, and consequences of INequalities in people with Dementia and their carers (DETERMIND): A protocol paper. Int J Geriatr Psychiatry. 2020;35(3):290-301. [Link] [DOI:10.1002/gps.5246]
16. Velilla L, Acosta-Baena N, Allen I, Lopera F, Kramer J. Analysis of family stigma and socioeconomic factors impact among caregivers of patients with early-and late-onset Alzheimer's disease and frontotemporal dementia. Sci Rep. 2022;12(1):12663. [Link] [DOI:10.1038/s41598-022-16400-2]
17. Sörensen S, Conwell Y. Issues in dementia caregiving: Effects on mental and physical health, intervention strategies, and research needs. Am J Geriatr Psychiatry. 2011;19(6):491-6. [Link] [DOI:10.1097/JGP.0b013e31821c0e6e]
18. Schulz R, Martire LM. Family caregiving of persons with dementia: Prevalence, health effects, and support strategies. Am J Geriatr Psychiatry. 2004;12(3):240-9. [Link] [DOI:10.1097/00019442-200405000-00002]
19. Bowling A, Rowe G, Adams S, Sands P, Samsi K, Crane M, et al. Quality of life in dementia: A systematically conducted narrative review of dementia-specific measurement scales. Aging Ment Health. 2015;19(1):13-31. [Link] [DOI:10.1080/13607863.2014.915923]
20. Wimo A, Seeher K, Cataldi R, Cyhlarova E, Dielemann JL, Frisell O, et al. The worldwide costs of dementia in 2019. Alzheimers Dement. 2023;19(7):2865-73. [Link] [DOI:10.1002/alz.12901]
21. Lynch C. World Alzheimer report 2019: Attitudes to dementia, a global survey: Public health: Engaging people in ADRD research. Alzheimers Dement. 2020;16(S10):e038255. [Link] [DOI:10.1002/alz.038255]
22. Rabinovici GD, La Joie R. Amyloid-targeting monoclonal antibodies for Alzheimer disease. JAMA. 2023;330(6):507-9. [Link] [DOI:10.1001/jama.2023.11703]
23. Mok VCT, Lam BYK, Wong A, Ko H, Markus HS, Wong LKS. Early-onset and delayed-onset poststroke dementia-revisiting the mechanisms. Nat Rev Neurol. 2017;13:148-59. [Link] [DOI:10.1038/nrneurol.2017.16]
24. Gauthier S, Albert M, Fox N, Goedert M, Kivipelto M, Mestre-Ferrandiz J, et al. Why has therapy development for dementia failed in the last two decades?. Alzheimers Dement. 2016;12(1):60-4. [Link] [DOI:10.1016/j.jalz.2015.12.003]
25. Niotis K, Saperia C, Saif N, Carlton C, Isaacson RS. Alzheimer's disease risk reduction in clinical practice: A priority in the emerging field of preventive neurology. Nat Ment Health. 2024;2:25-40. [Link] [DOI:10.1038/s44220-023-00191-0]
26. Wolters FJ, Chibnik LB, Waziry R, Anderson R, Berr C, Beiser A, et al. Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium. Neurology. 2020;95(5):e519-31. [Link] [DOI:10.1212/WNL.0000000000010022]
27. Lecordier S, Manrique-Castano D, El Moghrabi Y, ElAli A. Neurovascular alterations in vascular dementia: Emphasis on risk factors. Front Aging Neurosci. 2021;13:727590. [Link] [DOI:10.3389/fnagi.2021.727590]
28. Takeda S, Rakugi H, Morishita R. Roles of vascular risk factors in the pathogenesis of dementia. Hypertens Res. 2020;43(3):162-7. [Link] [DOI:10.1038/s41440-019-0357-9]
29. Parial LL, Lam SC, Ho JYS, Suen LKP, Leung AYM. Public knowledge of the influence of modifiable cardiovascular risk factors on dementia: A systematic literature review and meta-analysis. Aging Ment Health. 2021;25(8):1395-409. [Link] [DOI:10.1080/13607863.2020.1786801]
30. Rolandi E, Zaccaria D, Vaccaro R, Abbondanza S, Pettinato L, Davin A, et al. Estimating the potential for dementia prevention through modifiable risk factors elimination in the real-world setting: A population-based study. Alzheimers Res Ther. 2020;12(1):94. [Link] [DOI:10.1186/s13195-020-00661-y]
31. Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413-46. [Link] [DOI:10.1016/S0140-6736(20)30367-6]
32. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. [Link] [DOI:10.1136/bmj.n71]
33. Albugami M, Qadi M, Almugbel F, Mohammed A. The demographic characteristics and the risk factors of dementia in Saudi elderly. Am J Psychiatry Neurosci. 2018;6(1):1-8. [Link] [DOI:10.11648/j.ajpn.20180601.11]
34. Argyropoulos K, Liatsos C. Prevalence and risk factors of dementia and depressive symptoms in the elderly: A cross-sectional study in west-Greece. Achaiki Iatriki. 2022;41(3):118-25. [Link]
35. Carr AL, Sluiman AJ, Grecian SM, Forster R, McLachlan S, Strachan MWJ, et al. Depression as a risk factor for dementia in older people with type 2 diabetes and the mediating effect of inflammation. Diabetologia. 2021;64(2):448-57. [Link] [DOI:10.1007/s00125-020-05301-6]
36. Geraets AFJ, Leist AK, Deckers K, Verhey FRJ, Schram MT, Köhler S. Contributions of modifiable risk factors to increased dementia risk in depression. Psychol Med. 2023;53(14):6583-91. [Link] [DOI:10.1017/S0033291722003968]
37. Gureje O, Ogunniyi A, Kola L, Abiona T. Incidence of and risk factors for dementia in the Ibadan study of aging. J Am Geriatr Soc. 2011;59(5):869-74. [Link] [DOI:10.1111/j.1532-5415.2011.03374.x]
38. Deng J, Cao C, Jiang Y, Peng B, Wang T, Yan K, et al. Prevalence and effect factors of dementia among the community elderly in Chongqing, China. Psychogeriatrics. 2018;18(5):412-20. [Link] [DOI:10.1111/psyg.12343]
39. Keskinoglu P, Giray H, Picakciefe M, Bilgic N, Ucku R. The prevalence and risk factors of dementia in the elderly population in a low socio-economic region of Izmir, Turkey. Arch Gerontol Geriatr. 2006;43(1):93-100. [Link] [DOI:10.1016/j.archger.2005.09.006]
40. Ragubathy PK, Adikane H. Prevalence of risk factors for dementia in elderly population in tribal area of Central India-A community-based cross-sectional study. J Med Sci Health. 2019;5(3):19-30. [Link] [DOI:10.46347/JMSH.2019.v05i03.004]
41. Ravaglia G, Forti P, Maioli F, Bastagli L, Montesi F, Pisacane N, et al. Endogenous sex hormones as risk factors for dementia in elderly men and women. J Gerontol A Biol Sci Med Sci. 2007;62(9):1035-41. [Link] [DOI:10.1093/gerona/62.9.1035]
42. Santabárbara J, Lopez-Anton R, De La Cámara C, Lobo E, Gracia-García P, Villagrasa B, et al. Clinically significant anxiety as a risk factor for dementia in the elderly community. Acta Psychiatr Scand. 2019;139(1):6-14. [Link] [DOI:10.1111/acps.12966]
43. Dos Santos CDS, De Bessa TA, Xavier AJ. Factors associated with dementia in elderly. Ciencia e Saude Coletiva. 2020;25(2):603-11. [Link] [DOI:10.1590/1413-81232020252.02042018]
44. Simons LA, Simons J, McCallum J, Friedlander Y. Lifestyle factors and risk of dementia: Dubbo study of the elderly. Med J Aust. 2006;184(2):68-70. [Link] [DOI:10.5694/j.1326-5377.2006.tb00120.x]
45. Suriastini NW, Turana Y, Supraptilah B, Wicaksono TY, Mulyanto ED. Prevalence and risk factors of dementia and caregiver's knowledge of the early symptoms of Alzheimer's disease. Aging Med Healthc. 2020;11(2):60-6. [Link] [DOI:10.33879/AMH.2020.065-1811.032]
46. Toure K, Coume M, Ndiaye M, Zunzunegui MV, Bacher Y, Diop AG, et al. Risk factors for dementia in a Senegalese elderly population aged 65 years and over. Dement Geriatr Cogn Dis Extra. 2012;2(1):160-8. [Link] [DOI:10.1159/000332022]
47. Wallensten J, Ljunggren G, Nager A, Wachtler C, Bogdanovic N, Petrovic P, et al. Stress, depression, and risk of dementia-a cohort study in the total population between 18 and 65 years old in Region Stockholm. Alzheimers Res Ther. 2023;15(1):161. [Link] [DOI:10.1186/s13195-023-01308-4]
48. Wei CJ, Cheng Y, Zhang Y, Sun F, Zhang WS, Zhang MY. Risk factors for dementia in highly educated elderly people in Tianjin, China. Clin Neurol Neurosurg. 2014;122:4-8. [Link] [DOI:10.1016/j.clineuro.2014.04.004]
49. Fiske A, Wetherell JL, Gatz M. Depression in older adults. Annu Rev Clin Psychol. 2009;5:363-89. [Link] [DOI:10.1146/annurev.clinpsy.032408.153621]
50. Sözeri-Varma G. Depression in the elderly: Clinical features and risk factors. Aging Dis. 2012;3(6):465-71. [Link]
51. Becker NB, Jesus SN, Joao KADR, Viseu JN, Martins RIS. Depression and sleep quality in older adults: A meta-analysis. Psychol Health Med. 2017;22(8):889-95. [Link] [DOI:10.1080/13548506.2016.1274042]
52. Haigh EAP, Bogucki OE, Sigmon ST, Blazer DG. Depression among older adults: A 20-year update on five common myths and misconceptions. Am J Geriatr Psychiatry. 2018;26(1):107-22. [Link] [DOI:10.1016/j.jagp.2017.06.011]
53. Mitchell AJ, Subramaniam H. Prognosis of depression in old age compared to middle age: A systematic review of comparative studies. Am J Psychiatry. 2005;162(9):1588-601. [Link] [DOI:10.1176/appi.ajp.162.9.1588]
54. Comijs HC, Nieuwesteeg J, Kok R, Van Marwijk HW, Van Der Mast RC, Naarding P, et al. The two-year course of late-life depression; Results from the Netherlands study of depression in older persons. BMC Psychiatry. 2015;15:20. [Link] [DOI:10.1186/s12888-015-0401-5]
55. Beghi M, Butera E, Cerri CG, Cornaggia CM, Febbo F, Mollica A, et al. Suicidal behaviour in older age: A systematic review of risk factors associated to suicide attempts and completed suicides. Neurosci Biobehav Rev. 2021;127:193-211. [Link] [DOI:10.1016/j.neubiorev.2021.04.011]
56. Nouchi R, Taki Y, Takeuchi H, Sekiguchi A, Hashizume H, Nozawa T, et al. Four weeks of combination exercise training improved executive functions, episodic memory, and processing speed in healthy elderly people: Evidence from a randomized controlled trial. Age. 2014;36(2):787-99. [Link] [DOI:10.1007/s11357-013-9588-x]
57. Eikelboom WS, Bertens D, Kessels RPC. Cognitive rehabilitation in normal aging and individuals with subjective cognitive decline. In: Cognitive rehabilitation and neuroimaging. Cham: Springer; 2020. p. 37-67. [Link] [DOI:10.1007/978-3-030-48382-1_3]
58. Jia L, Du Y, Chu L, Zhang Z, Li F, Lyu D, et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: A cross-sectional study. Lancet Public Health. 2020;5(12):e661-71. [Link] [DOI:10.1016/S2468-2667(20)30185-7]
59. Dumitriu D, Hao J, Hara Y, Kaufmann J, Janssen WGM, Lou W, et al. Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairment. J Neurosci. 2010;30(22):7507-15. [Link] [DOI:10.1523/JNEUROSCI.6410-09.2010]
60. Burke SN, Barnes CA. Neural plasticity in the ageing brain. Nat Rev Neurosci. 2006;7:30-40. [Link] [DOI:10.1038/nrn1809]
61. Kuehner C. Why is depression more common among women than among men?. Lancet Psychiatry. 2017;4(2):146-58. [Link] [DOI:10.1016/S2215-0366(16)30263-2]
62. Albert PR. Why is depression more prevalent in women?. J Psychiatry Neurosci. 2015;40(4):219-21. [Link] [DOI:10.1503/jpn.150205]
63. Kundakovic M, Rocks D. Sex hormone fluctuation and increased female risk for depression and anxiety disorders: From clinical evidence to molecular mechanisms. Front Neuroendocrinol. 2022;66:101010. [Link] [DOI:10.1016/j.yfrne.2022.101010]
64. Snowden MB, Steinman LE, Bryant LL, Cherrier MM, Greenlund KJ, Leith KH, et al. Dementia and co‐occurring chronic conditions: a systematic literature review to identify what is known and where are the gaps in the evidence?. Int J Geriatr Psychiatry. 2017;32(4):357-71. [Link] [DOI:10.1002/gps.4652]
65. Rost NS, Brodtmann A, Pase MP, Van Veluw SJ, Biffi A, Duering M, et al. Post-stroke cognitive impairment and dementia. Circ Res. 2022;130(8):1252-71. [Link] [DOI:10.1161/CIRCRESAHA.122.319951]
66. Sierra C. Hypertension and the risk of dementia. Front Cardiovasc Med. 2020;7:5. [Link] [DOI:10.3389/fcvm.2020.00005]
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