Tarbiat Modares University (TMU) Health Education and Health Promotion 2588-5715 14 2 2026 07 01 Health Literacy as a Predictor of Health-Promoting Lifestyle in Cardiovascular Patients: A Population-Based Study in Southeast Iran 29159 EN F. Azaryan H. Izadirad 0000-0002-9067-8661 M. Dadvand Journal Article 2026 07 10 Background and Objective: Cardiovascular diseases (CVDs) are a leading cause of mortality worldwide and in Iran. Health literacy (HL) is a crucial factor in managing such conditions. This study aimed to examine the relationship between HL and health-promoting behaviors (HPBs) among patients with CVD in Khāsh, southeast Iran.<br>Methods: In this cross-sectional study, 350 CVD patients from Imam Khomeini Hospital in Khāsh were selected via convenience sampling. Data were collected using two validated instruments: the Short Form of the Health Literacy for Iranian Adults (HELIA-SF) and the Walker Health-Promoting Lifestyle Profile (HPLP-II). Data analysis was performed using Pearson’s correlation, multiple linear regression, and ANOVA in SPSS-24.<br>Results: The mean HL score was 36.25 ± 22.65, indicating a poor overall level. HPBs were moderate (139.84 ± 21.74), with the lowest score in physical activity (20.54 ± 4.39). HL showed the strongest correlation with physical activity (r = 0.632, p < 0.001) and the weakest with stress management (r = 0.297, p < 0.001). Regression analysis identified HL as the strongest predictor of HPBs (β = 0.666, p < 0.001), followed by basic HL skills (β = 0.435) and decision-making skills (β = 0.330). The model explained approximately 52% of the variance in HPBs (R² = 0.524).<br>Conclusion: HL is the most significant predictor of health-promoting behaviors in CVD patients. These findings underscore the need for targeted educational interventions—particularly in underserved regions—to improve HL and promote healthier lifestyles, thereby reducing the burden of cardiovascular disease. https://hehp.modares.ac.ir/article_29159_9d64e8c6bacfd2a98415686a6af75cfd.pdf